Please contact us at: 732-758-6511

Intrauterine Insemination

One of the simplest forms of infertility treatment is performing an intrauterine insemination or IUI. This is one of the least invasive methods of treatment for infertility and some insurances actually require several attempts of IUI before moving on to IVF.

In order to participate in this form of treatment, one or both of a woman’s fallopian tubes must be open or patent and free of scarring or infection. This means that sperm can travel freely from the uterus through the tubes to the awaiting egg for fertilization.

IUI is a relatively simple procedure that takes little time to perform. During IUI, a catheter is passed through the cervix, into the uterus. Contained within the catheter are sperm, which are injected into the uterus. The whole procedure may take only a few minutes.

A woman can try IUIs using several approaches:

Natural Cycle IUI

A woman monitors her temperature using a basal thermometer and charts her temperature every morning. There are no fertility drugs used to suppress or stimulate the ovaries. Around the time of expected ovulation the patient checks for an LH surge (around day 14) using test strips that are placed in a urine sample. Once the surge is detected insemination should occur 24 to 36 hours later.


Clomid IUI

The goal of clomiphene therapy in treating infertility is to establish normal ovulation rather than cause the development of numerous eggs. Once ovulation is established, there is no benefit to increasing the dosage further. Numerous studies show that pregnancy usually occurs during the first three months of infertility therapy and treatment beyond six months is not recommended. Clomiphene can cause side effects such as ovarian hyperstimulation (rare), visual disturbances, nausea, diminished “quality” of the cervical mucus, multiple births, and others.

Clomid is often prescribed as a “first line” ovulation induction therapy. Most patients should undergo the fertility “workup” prior to beginning any therapy. There could be many causes of infertility in addition to ovulatory disorders, including endometriosis, tubal disease, cervical factor and others.

Superovulation IUI

Fertility medicines are administered to increase the number of follicles that develop for a given IUI cycle. Fertility drugs containing FSH are injected daily to achieve this result. Vaginal ultrasound examinations are performed during the course of fertility medication treatment. This exam will evaluate follicle and uterine lining development. Blood tests for estradiol will also be performed in conjunction with the ultrasounds. Treatment decisions regarding dose of fertility medicines and need for further visits will depend upon the ultrasound and estradiol blood test results. HCG is administered when the doctor feels follicle size and estradiol levels are optimal for insemination. After the HCG shot the IUI will be performed 24 to 36 hours later.

The following are potential risks and side effects associated with fertility medications: Nausea, vomiting, hot flashes, headaches, mood swings, visual symptoms, ovarian hyperstimulation, premature LH surge, ovarian torsion, bruising at the venipuncture site and irritation at the injection site. Allergic reactions, although rare, are also possible. There is data available that suggests superovulatory drugs may increase the risk of ovarian cancer.

What about the sperm?

IUI’s need sperm in order to be successful. Most often partners produce a sperm sample the morning of the IUI, within one hour of the scheduled drop off time.  The sperm is separated from the seminal fluid in the laboratory. Dead or disfigured sperm are filtered out, leaving a concentrated sample of swimming sperm.

If it has been anticipated that partner will not be available on the day of an IUI a sperm sample can be collected in the weeks prior to treatment and frozen. This is not the optimal situation and should only be used when absolutely necessary.

If a woman does not have a male partner, frozen donor sperm either from a known or anonymous man can be used. Please see our IVF Donor Program for further information.

Success with IUI

Natural IUIs, meaning that no fertility drugs were used, tend to have lower success rates, dipping down to about 6% in some cases. However, IUIs done with fertility drugs that produce multiple eggs have success rates of up to 30% associated with them. Additionally, sperm count greatly affects the outcome with IUI.

Using sperm samples with a smaller count often cause a couple to have less success. Overall, though, a success rate of 15% to 20% is associated with IUI.

Post insemination care

Progesterone is a hormone made by the ovary that prepares the lining of the uterus for implantation. Studies have shown that supplemental progesterone following superovulation may decrease the possibility of miscarriage. Natural progesterone is available and can be taken orally, administered intramuscularly or administered using a vaginal gel. Progesterone support begins once a conception occurs and is continued until the 10th week of pregnancy. There is no indication that a woman who takes natural progesterone supplements during pregnancy is at an increased risk of congenital anomalies developing in an unborn child.

A vaginal ultrasound will be performed approximately four weeks after the day of the insemination to determine the status of the pregnancy.


Damien Fertility Partners
655 Shrewsbury Avenue
Shrewsbury, NJ 07702
Phone: 732-758-6511
Fax: 732-758-1048


Damien Fertility Partners
60 Park Place, Suite 210
Newark, NJ 07102
Phone: 973-732-2909
Fax: 732-758-1048

Jersey City

Damien Fertility Partners
138 River Drive South
Jersey City, NJ 07310
Phone: 201-377-0500
Fax: 732-758-1048